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Trans R Soc Trop Med Hyg. 1988;82(1):37-8.

Evidence of increased chloroquine sensitivity in Thai isolates of Plasmodium falciparum.

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  • 1Department of Biology, Chulalongkorn University, Bangkok, Thailand.


Sensitivity of Thai isolates of Plasmodium falciparum to chloroquine collected over the years 1978-1986 was measured by two methods: (i) by growth of previously cultured isolates for 72 h in presence of drug, and (ii) by the WHO standard in vitro microtest. During this period there were signs of a gradual increase in drug sensitivity, coinciding with the withdrawal of chloroquine for treatment of falciparum malaria in Thailand.

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