Testing for funnel plot asymmetry of standardized mean differences

Res Synth Methods. 2019 Mar;10(1):57-71. doi: 10.1002/jrsm.1332. Epub 2019 Jan 8.

Abstract

Publication bias and other forms of outcome reporting bias are critical threats to the validity of findings from research syntheses. A variety of methods have been proposed for detecting selective outcome reporting in a collection of effect size estimates, including several methods based on assessment of asymmetry of funnel plots, such as the Egger's regression test, the rank correlation test, and the Trim-and-Fill test. Previous research has demonstated that the Egger's regression test is miscalibrated when applied to log-odds ratio effect size estimates, because of artifactual correlation between the effect size estimate and its standard error. This study examines similar problems that occur in meta-analyses of the standardized mean difference, a ubiquitous effect size measure in educational and psychological research. In a simulation study of standardized mean difference effect sizes, we assess the Type I error rates of conventional tests of funnel plot asymmetry, as well as the likelihood ratio test from a three-parameter selection model. Results demonstrate that the conventional tests have inflated Type I error due to the correlation between the effect size estimate and its standard error, while tests based on either a simple modification to the conventional standard error formula or a variance-stabilizing transformation both maintain close-to-nominal Type I error.

Keywords: meta-analysis; outcome reporting bias; publication bias; standardized mean difference.

MeSH terms

  • Animals
  • Computer Simulation
  • Data Interpretation, Statistical*
  • Humans
  • Likelihood Functions
  • Models, Statistical
  • Monte Carlo Method
  • Odds Ratio*
  • Programming Languages
  • Publication Bias*
  • Reference Standards
  • Regression Analysis
  • Reproducibility of Results
  • Research Design*
  • Sample Size