Synergistic effects of fast-neutron dose per epithermal neutron and 10B concentration on relative-biological-effectiveness dose for accelerator-based boron neutron capture therapy

F Hiraga; T Ooie

doi:10.1016/j.apradiso.2018.11.003

Synergistic effects of fast-neutron dose per epithermal neutron and ¹⁰B concentration on relative-biological-effectiveness dose for accelerator-based boron neutron capture therapy

Appl Radiat Isot. 2019 Feb:144:1-4. doi: 10.1016/j.apradiso.2018.11.003. Epub 2018 Nov 12.

Authors

F Hiraga¹, T Ooie²

Affiliations

¹ Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan. Electronic address: hiraga@eng.hokudai.ac.jp.
² Graduate school of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan. Electronic address: o_tac@eis.hokudai.ac.jp.

PMID: 30465991
DOI: 10.1016/j.apradiso.2018.11.003

Abstract

The efficacy of accelerator-based boron neutron capture therapy was examined through relative-biological-effectiveness dose calculations with the fast-neutron dose per epithermal neutron (FNR) and the ¹⁰B concentration as parameters. In the case of a tumor ¹⁰B concentration of 65 ppm, the treatment efficacy depended more strongly on the FNR when the normal-tissue ¹⁰B concentration was 0.65 ppm, which would be brought about by the administration of an advanced chemical compound, than when the ¹⁰B concentration was 18 ppm, which is attainable by the use of boronophenylalanine.

Keywords: (10)B concentration; Accelerator-based boron neutron capture therapy: Treatment efficacy; Epithermal neutrons; Fast neutron dose; Relative biological effectiveness dose.

MeSH terms

Boron Neutron Capture Therapy / methods*
Fast Neutrons*
Humans
Monte Carlo Method
Neoplasms / radiotherapy
Phantoms, Imaging
Radiotherapy Dosage*
Relative Biological Effectiveness*