Unlocking the Dangers of a Stiffening Brain

Shelly Kaushik; Anders I Persson

doi:10.1016/j.neuron.2018.11.011

Unlocking the Dangers of a Stiffening Brain

Neuron. 2018 Nov 21;100(4):763-765. doi: 10.1016/j.neuron.2018.11.011.

Authors

Shelly Kaushik¹, Anders I Persson²

Affiliations

¹ Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.
² Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA. Electronic address: anders.persson@ucsf.edu.

PMID: 30465758
DOI: 10.1016/j.neuron.2018.11.011

Abstract

Mechanical cues regulate neuronal function and reactivity of glial cells, the origin of gliomas. In this issue of Neuron, Chen et al. (2018) uncover a feedforward loop mediated by the mechanosensitive ion channel Piezo1 and tissue stiffness that drives glioma aggression.

Publication types

Comment

MeSH terms

Aggression*
Brain
Glioma*
Humans
Ion Channels
Neurons

Substances

Ion Channels
PIEZO1 protein, human