Nanodiamonds conjugated upconversion nanoparticles for bio-imaging and drug delivery

Kuikui Zhang; Qi Zhao; Shirong Qin; Yang Fu; Runze Liu; Jinfang Zhi; Chongxin Shan

doi:10.1016/j.jcis.2018.11.028

Nanodiamonds conjugated upconversion nanoparticles for bio-imaging and drug delivery

J Colloid Interface Sci. 2019 Mar 1:537:316-324. doi: 10.1016/j.jcis.2018.11.028. Epub 2018 Nov 10.

Authors

Kuikui Zhang¹, Qi Zhao², Shirong Qin¹, Yang Fu³, Runze Liu³, Jinfang Zhi⁴, Chongxin Shan⁵

Affiliations

¹ Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China.
² Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address: zhaoqiv@126.com.
³ Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
⁴ Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: zhi-mail@mail.ipc.ac.cn.
⁵ Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450001, China. Electronic address: cxshan@zzu.edu.cn.

PMID: 30448652
DOI: 10.1016/j.jcis.2018.11.028

Abstract

A multifunctional nanoplatform with simultaneous imaging and therapeutic capacities has been fabricated by covalently conjugating nanodiamonds (NDs) with upconversion NaYF₄:Yb,Er nanoparticles (UCNPs). Green emission can be observed for the UCNP-NDs composites under 980 nm excitation, and in vitro imaging was carried out towards HeLa cells. The UCNP-NDs also shows good drug storage capability toward anticancer drug doxorubicin (Dox) and exhibits significant pH-dependent drug-release behavior. Dox-loaded UCNP-NDs shows higher therapy efficiency towards Hela cells than free Dox when the equivalent concentration of the Dox is more than 10 μg/mL. Thus, a favorable strategy may be provided to decrease the side effects of Dox, minimize drug dose, and improve its efficacy. These findings highlight the fascinating features of UCNP-NDs nanocomposites as upconversion fluorescence imaging contrast agents and doxorubicin loading carrier. In addition, this work may also provide a novel strategy for the design of multifunctional nanoplatforms.

Keywords: Cell imaging; Drug delivery; Nanodiamonds; Upconversion nanoparticles.

MeSH terms

Antineoplastic Agents / administration & dosage*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Proliferation / drug effects
Contrast Media / chemistry
Dose-Response Relationship, Drug
Doxorubicin / administration & dosage*
Doxorubicin / chemistry
Doxorubicin / pharmacology
Drug Delivery Systems*
Drug Screening Assays, Antitumor
Female
HeLa Cells
Humans
Nanoparticles / chemistry*
Optical Imaging*
Particle Size
Structure-Activity Relationship
Surface Properties
Uterine Cervical Neoplasms / diagnostic imaging*
Uterine Cervical Neoplasms / drug therapy*

Substances

Antineoplastic Agents
Contrast Media
Doxorubicin