Mol Cell Biol. 1988 Jun;8(6):2651-4.

B-raf, a new member of the raf family, is activated by DNA rearrangement.

Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K.

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Department of Oncology, University of Tokyo, Japan.

Abstract

Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene.

PMID:: 3043188; [PubMed - indexed for MEDLINE]
PMCID:: PMC363468

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Molecular cloning and characterization of an activated human c-raf-1 gene. [Mol Cell Biol. 1987]
Molecular cloning and characterization of an activated human c-raf-1 gene.
Fukui M, Yamamoto T, Kawai S, Mitsunobu F, Toyoshima K. Mol Cell Biol. 1987 May; 7(5):1776-81.
B-raf oncogene: activation by rearrangements and assignment to human chromosome 7. [Jpn J Cancer Res. 1993]
B-raf oncogene: activation by rearrangements and assignment to human chromosome 7.
Kamiyama T, Aoki N, Yuasa Y. Jpn J Cancer Res. 1993 Mar; 84(3):250-6.
Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene. [Oncogene. 1992]
Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.
Eychène A, Barnier JV, Apiou F, Dutrillaux B, Calothy G. Oncogene. 1992 Aug; 7(8):1657-60.
Review Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. [Oncogene. 1990]
Review Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.
Sithanandam G, Kolch W, Duh FM, Rapp UR. Oncogene. 1990 Dec; 5(12):1775-80.
Review The human met oncogene is a member of the tyrosine kinase family. [Princess Takamatsu Symp. 1986]
Review The human met oncogene is a member of the tyrosine kinase family.
Gonzatti-Haces M, Park M, Dean M, Blair DG, Vande Woude GF. Princess Takamatsu Symp. 1986; 17:221-32.

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Cited by 25 PubMed Central articles

Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase. [J Biol Chem. 2011]
Single substitution within the RKTR motif impairs kinase activity but promotes dimerization of RAF kinase.
Baljuls A, Mahr R, Schwarzenau I, Müller T, Polzien L, Hekman M, Rapp UR. J Biol Chem. 2011 May 6; 286(18):16491-503. Epub 2011 Mar 18.
B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. [PLoS One. 2010]
B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse.
Valluet A, Hmitou I, Davis S, Druillennec S, Larcher M, Laroche S, Eychène A. PLoS One. 2010 Dec 22; 5(12):e15272. Epub 2010 Dec 22.
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms. [Mol Cell Biol. 2007]
Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms.
Hmitou I, Druillennec S, Valluet A, Peyssonnaux C, Eychène A. Mol Cell Biol. 2007 Jan; 27(1):31-43. Epub 2006 Oct 30.

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