Primary idiopathic CNS non-amyloidogenic light chain deposition disease complicated by treatment-resistant focal seizure disorder

Brian T Grainger; Samar Issa; Neil E Anderson

doi:10.1016/j.jocn.2018.10.123

Primary idiopathic CNS non-amyloidogenic light chain deposition disease complicated by treatment-resistant focal seizure disorder

J Clin Neurosci. 2019 Jan:59:313-315. doi: 10.1016/j.jocn.2018.10.123. Epub 2018 Nov 10.

Authors

Brian T Grainger¹, Samar Issa², Neil E Anderson³

Affiliations

¹ Department of Haematology, Middlemore Hospital, Auckland, New Zealand.
² Department of Haematology, Middlemore Hospital, Auckland, New Zealand. Electronic address: Samar.Issa@middlemore.co.nz.
³ Department of Neurology, Auckland City Hospital, Auckland, New Zealand.

PMID: 30424969
DOI: 10.1016/j.jocn.2018.10.123

Abstract

Light chain deposition disease (LCDD) is a systemic disorder characterised by the pathologic deposition of immunoglobulin light chains, which is histologically distinguished from amyloidosis by failure to stain with Congo red. Central nervous system (CNS)-restricted LCDD is among the rarest manifestations. We describe a unique case complicated by focal onset epilepsy with impaired awareness for which control with anticonvulsant therapy proved difficult.

Publication types

Case Reports

MeSH terms

Amyloidosis / complications
Amyloidosis / pathology*
Central Nervous System / pathology*
Epilepsies, Partial / complications*
Female
Humans
Immunoglobulin Light Chains / metabolism*
Middle Aged

Substances

Immunoglobulin Light Chains