Mechanisms of action of Ru(ii) polypyridyl complexes in living cells upon light irradiation

Chem Commun (Camb). 2018 Nov 20;54(93):13040-13059. doi: 10.1039/c8cc05928d.

Abstract

The unique photophysical properties of Ru(ii) polypyridyl complexes make them very attractive candidates as photosensitisers in Photodynamic Therapy (PDT). However, to date, there are not many studies exploring in detail the mechanism(s) of action of such compounds in living systems upon light irradiation. This feature article provides an overview of the most in-depth biological studies on such compounds.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Humans
  • Light*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Photochemotherapy*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Polymers / chemistry
  • Polymers / pharmacology
  • Pyridines / chemistry
  • Pyridines / pharmacology
  • Ruthenium / chemistry
  • Ruthenium / pharmacology

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Photosensitizing Agents
  • Polymers
  • Pyridines
  • Ruthenium