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Human delta-aminolevulinate dehydratase: chromosomal localization to 9q34 by in situ hybridization.
The structural gene for human delta-aminolevulinate dehydratase (ALA-D) has been localized to chromosomal region 9q34 by in situ hybridization using a [125I]-labeled human delta-aminolevulinate dehydratase cDNA. Of the 150 silver grains analyzed, 25% were localized to chromosome 9q, while 12% and 8% were on chromosomes 1p and 13q, respectively. The single chromosomal region q34 had over 90% of the total grains observed on chromosome 9. In contrast, the grains on chromosomes 1p and 13q were dispersed, consistent with the absence of any human ALA-D pseudogenes. Southern blot analysis of somatic cell hybrids informative for ALA-D (Wang et al. 1985) also was consistent and supported the finding of only one locus for this heme biosynthetic enzyme.
PMID: 3036687 [PubMed - indexed for MEDLINE]
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Cited by 8 PubMed Central articles
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Associations of blood pressure and hypertension with lead dose measures and polymorphisms in the vitamin D receptor and delta-aminolevulinic acid dehydratase genes.
Lee BK, Lee GS, Stewart WF, Ahn KD, Simon D, Kelsey KT, Todd AC, Schwartz BS.
Environ Health Perspect. 2001 Apr; 109(4):383-9.
[Environ Health Perspect. 2001]
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Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with polymorphisms in the vitamin D receptor and [delta]-aminolevulinic acid dehydratase genes.
Schwartz BS, Lee BK, Lee GS, Stewart WF, Simon D, Kelsey K, Todd AC.
Environ Health Perspect. 2000 Oct; 108(10):949-54.
[Environ Health Perspect. 2000]
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ReviewGenetic susceptibility to lead poisoning.
Onalaja AO, Claudio L.
Environ Health Perspect. 2000 Mar; 108 Suppl 1:23-8.
[Environ Health Perspect. 2000]
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