Send to:

Choose Destination
See comment in PubMed Commons below
Pharmacopsychiatry. 1987 Mar;20(2):37-47.

Is there a common denominator for the antimanic effect of lithium and anticonvulsants?


Starting from the idea that different primary actions of carbamazepine, valproate and lithium might converge into a similar secondary mechanism of action, e.g. a modulation of the functioning of certain transmitter systems, a review of the literature was made on the effects of these and related substances on GABAergic, dopaminergic, cholinergic, noradrenergic and serotonergic transmission, in an attempt to find a common denominator. It was concluded that similarities of the effects of these drugs are most evident with respect to a reduction of dopaminergic transmission. Some similarities also exist with respect to GABAergic and, to a lesser degree, cholinergic transmission. The effects on noradrenergic and serotonergic transmission seem too disparate to be considered as a potential basis for the antimanic effects of these drugs.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Georg Thieme Verlag Stuttgart, New York
    Loading ...
    Write to the Help Desk