Platelet binding studies in panic disorder

J Affect Disord. 1987 Jan-Feb;12(1):7-11. doi: 10.1016/0165-0327(87)90055-3.

Abstract

Binding parameters of the alpha 2-adrenoceptor (using [3H]yohimbine) and the 5-HT uptake site (using [3H]imipramine) were measured in intact platelets in a group of 15 patients with a DSM-III diagnosis of panic disorder. When compared with an age- and sex-matched control population no differences in either Bmax or Kd were found. This result is discussed in light of the reports of platelet binding abnormalities in depression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anxiety Disorders / blood*
  • Blood Platelets / metabolism*
  • Fear / physiology*
  • Female
  • Humans
  • Imipramine / blood
  • Male
  • Middle Aged
  • Panic / physiology*
  • Receptors, Adrenergic, alpha / metabolism*
  • Receptors, Serotonin / metabolism*
  • Yohimbine / blood

Substances

  • Receptors, Adrenergic, alpha
  • Receptors, Serotonin
  • Yohimbine
  • Imipramine