Hum Genet. 1987 May;76(1):66-72.

Human ferritin H and L sequences lie on ten different chromosomes.

McGill JR, Naylor SL, Sakaguchi AY, Moore CM, Boyd D, Barrett KJ, Shows TB, Drysdale JW.

Abstract

In humans, the H (heavy) and L (light) chains of the iron-storage protein ferritin, are derived from multigene families. We have examined the chromosomal distribution of these H and L sequences by Southern analysis of hybrid cell DNA and by chromosomal in situ hybridization. Our results show that human ferritin H genes and related sequences are found on at least seven different chromosomes while L genes and related sequences are on at least three different chromosomes. Further, we have mapped the chromosomal location of expressed genes for human H and L ferritin chains and have found an H sequence which may be a useful marker for idiopathic hemochromatosis.

PMID:: 3032771; [PubMed - indexed for MEDLINE]

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