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Experientia. 1987 Apr 15;43(4):402-3.

A major metabolite of delta 1-tetrahydrocannabinol reduces its cataleptic effect in mice.


The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of delta 1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.

[PubMed - indexed for MEDLINE]
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