A major metabolite of delta 1-tetrahydrocannabinol...[Experientia. 1987]

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1: Experientia. 1987 Apr 15;43(4):402-3.Links

A major metabolite of delta 1-tetrahydrocannabinol reduces its cataleptic effect in mice.

Burstein S, Hunter SA, Latham V, Renzulli L.

The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of delta 1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.

PMID: 3032669 [PubMed - indexed for MEDLINE]

Prostaglandins and cannabis--XVI. Antagonism of delta 1-tetrahydrocannabinol action by its metabolites.
Biochem Pharmacol. 1986 Aug 1; 35(15):2553-8.

[Biochem Pharmacol. 1986]
Immunization against prostaglandins reduces delta 1-tetrahydrocannabinol-induced catalepsy in mice.
Mol Pharmacol. 1989 Jan; 35(1):6-9.

[Mol Pharmacol. 1989]
Cannabinoids and pain responses: a possible role for prostaglandins.
FASEB J. 1988 Nov; 2(14):3022-6.

[FASEB J. 1988]
Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
J Pharm Pharmacol. 1988 Feb; 40(2):132-4.

[J Pharm Pharmacol. 1988]
ReviewAjulemic acid (CT3): a potent analog of the acid metabolites of THC.
Curr Pharm Des. 2000 Sep; 6(13):1339-45.

[Curr Pharm Des. 2000]
» See reviews... | » See all...

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