Increased mitochondrial DNA copy number in maternal peripheral blood is associated with low birth weight in Lombok, Indonesia

L Priliani; C A Febinia; B Kamal; A H Shankar; S G Malik

doi:10.1016/j.placenta.2018.08.001

Increased mitochondrial DNA copy number in maternal peripheral blood is associated with low birth weight in Lombok, Indonesia

Placenta. 2018 Oct:70:1-3. doi: 10.1016/j.placenta.2018.08.001. Epub 2018 Aug 9.

Authors

L Priliani¹, C A Febinia¹, B Kamal², A H Shankar³, S G Malik⁴

Affiliations

¹ Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia.
² Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia.
³ Summit Institute of Development, Mataram, Nusa Tenggara Barat, Indonesia; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address: ashankar@hsph.harvard.edu.
⁴ Eijkman Institute for Molecular Biology, Ministry of Research, Technology and Higher Education, Jalan Diponegoro no. 69, Jakarta, 10430, Indonesia. Electronic address: ina@eijkman.go.id.

PMID: 30316321
DOI: 10.1016/j.placenta.2018.08.001

Abstract

Fetal development depends on maternal metabolic energy from mitochondria. We investigated the association of maternal mitochondrial function, represented by mitochondrial DNA copy number (mtDNA-CN) of venous blood, with child birth weight (BW) from 528 randomly selected mothers enrolled in the Supplementation with Multiple Micronutrients Intervention Trial (ISRCTN 34151616). Real-time quantitative PCR of archived blood specimens and regression analysis adjusting for other primary determinants of BW showed that log_e mtDNA-CN was inversely associated with BW (β = -204.6, p < 0.001), particularly in the third trimester (β = -376.8, p<0.001). Maternal mtDNA-CN may be a marker for low BW and fetal growth restriction.

Keywords: Birth weight; mtDNA copy number.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Birth Weight / physiology*
DNA Copy Number Variations / physiology*
DNA, Mitochondrial / genetics*
Female
Humans
Indonesia
Infant, Low Birth Weight / physiology*
Infant, Newborn
Male
Pregnancy
Risk Factors

Substances

DNA, Mitochondrial