Biologically significant scavenging of the myelope...[FEBS Lett. 1987]

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1: FEBS Lett. 1987 Mar 9;213(1):15-7. Links

Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.

Halliwell B, Wasil M, Grootveld M.

Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint, may therefore facilitate proteolytic damage.

PMID: 3030805 [PubMed - indexed for MEDLINE]

Action of uric acid, allopurinol and oxypurinol on the myeloperoxidase-derived oxidant hypochlorous acid. [Free Radic Res Commun. 1987]
The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. [Free Radic Biol Med. 1989]
Allopurinol and oxypurinol are hydroxyl radical scavengers. [FEBS Lett. 1987]
ReviewBiomarkers of myeloperoxidase-derived hypochlorous acid. [Free Radic Biol Med. 2000]
ReviewCefoperazone prevents the inactivation of alpha(1)-antitrypsin by activated neutrophils. [Antimicrob Agents Chemother. 1999]

Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate®, Cevi-Bid®, ...) Ascorbic acid is used to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.

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Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by ascorbic acid. Implications for antioxidant protection in the inflamed rheumatoid joint.

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