Curr Eye Res. 1987 Jan;6(1):241-5.

Anti-herpes simplex virus (HSV) effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea.

Abstract

The anti-herpes simplex virus (HSV) effect and cytotoxicity of a new nucleoside analogue, 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea were studied. In tests of the anti-HSV effect of DHPG, even 0.03% ointment, given 5 times per day for 2 days, prevented lesion formation. The preventive effect of DHPG was much stronger than that of acyclovir (ACV) or 5-iodo-2'-deoxyuridine (IDU). In tests on the therapeutic effect of DHPG against dendritic ulcers, 0.3% ointment, given 5 times per day for 4 days, had a dramatic therapeutic effect. The effect was stronger than that of 3% ACV or 0.5% IDU ointment. Application of 0.3%, 1% or 3% DHPG ointment to normal rabbit corneas, 5 times per day for 2 weeks resulted in no histopathological abnormalities. The above results show that DHPG is superior to ACV or IDU for treatment of HSV infections.

PMID:: 3030645; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

[Experimental studies of 9-(1, 3-dihydroxy-2-propoxymethyl)-guanine(DHPG) against herpes simplex virus]. [Yao Xue Xue Bao. 1989]
[Experimental studies of 9-(1, 3-dihydroxy-2-propoxymethyl)-guanine(DHPG) against herpes simplex virus].
Chen ZJ, Liu WG, Song JZ. Yao Xue Xue Bao. 1989; 24(5):331-4.
Comparative efficacy of three antiviral drugs in mice herpetic keratitis. [Jpn J Ophthalmol. 1989]
Comparative efficacy of three antiviral drugs in mice herpetic keratitis.
Inoue Y, Ohashi Y, Shimomura Y, Manabe R, Yamada M, Ueda S, Kato S. Jpn J Ophthalmol. 1989; 33(1):125-31.
Effects of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) eye drops and cyclosporine eye drops in the treatment of herpetic stromal keratitis in rabbits. [Curr Eye Res. 1991]
Effects of 9-(1,3-dihydroxy-2-propoxymethyl) guanine (DHPG) eye drops and cyclosporine eye drops in the treatment of herpetic stromal keratitis in rabbits.
Naito T, Nitta K, Kinouchi Y, Shiota H, Mimura Y. Curr Eye Res. 1991; 10 Suppl:201-3.
Review Herpesvirus infections (cytomegalovirus, herpes simplex virus, varicella-zoster virus). How to use ganciclovir (DHPG) and acyclovir. [Infect Dis Clin North Am. 1988]
Review Herpesvirus infections (cytomegalovirus, herpes simplex virus, varicella-zoster virus). How to use ganciclovir (DHPG) and acyclovir.
Drew WL, Buhles W, Erlich KS. Infect Dis Clin North Am. 1988 Jun; 2(2):495-509.
Review Acyclovir (Zovirax) ophthalmic ointment: a review of clinical tolerance. [Curr Eye Res. 1987]
Review Acyclovir (Zovirax) ophthalmic ointment: a review of clinical tolerance.
Grant DM. Curr Eye Res. 1987 Jan; 6(1):231-5.

See reviews... See all...

Cited by 3 PubMed Central articles

Topical ganciclovir in the treatment of acute herpetic keratitis. [Clin Ophthalmol. 2010]
Topical ganciclovir in the treatment of acute herpetic keratitis.
Tabbara KF, Al Balushi N. Clin Ophthalmol. 2010 Aug 19; 4:905-12. Epub 2010 Aug 19.
Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes. [Clin Ophthalmol. 2007]
Ganciclovir ophthalmic gel, 0.15%: a valuable tool for treating ocular herpes.
Colin J. Clin Ophthalmol. 2007 Dec; 1(4):441-53.
Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study. [Br J Ophthalmol. 1996]
Randomised trial of ganciclovir and acyclovir in the treatment of herpes simplex dendritic keratitis: a multicentre study.
Hoh HB, Hurley C, Claoue C, Viswalingham M, Easty DL, Goldschmidt P, Collum LM. Br J Ophthalmol. 1996 Feb; 80(2):140-3.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Anti-herpes simplex virus (HSV) effect of 9-(1,3-dihydroxy-2-propoxymethyl)guani...
Anti-herpes simplex virus (HSV) effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea.
Curr Eye Res. 1987 Jan ;6(1):241-5.

PubMed
Adenoid cystic carcinoma of the breast. Data from the Connecticut Tumor Registry...
Adenoid cystic carcinoma of the breast. Data from the Connecticut Tumor Registry and a review of the literature.
Ann Surg. 1987 Mar ;205(3):295-301.

PubMed
Marital quality, marital disruption, and immune function.
Marital quality, marital disruption, and immune function.
Psychosom Med. 1987 Jan-Feb ;49(1):13-34.

PubMed
Physical analysis of the COR region: a cluster of six genes in Saccharomyces cer...
Physical analysis of the COR region: a cluster of six genes in Saccharomyces cerevisiae.
Mol Cell Biol. 1987 Feb ;7(2):632-8.

PubMed
Molecular cloning and characterization of cDNA for human myeloperoxidase.
Molecular cloning and characterization of cDNA for human myeloperoxidase.
J Biol Chem. 1987 Mar 15 ;262(8):3844-51.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: