Biochem J. 1986 Dec 15;240(3):783-7.

Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.

Abstract

The sequencing of human liver cDNA clones encoding the entire C1r precursor protein has confirmed the previously determined peptide sequence and has shown that there is a leader peptide which is 17 amino acids long. A residue tentatively identified as beta-hydroxyaspartic acid [Arlaud, Willis & Gagnon (1986) Biochem. J., in the press] located in the C1r A-chain, within an epidermal-growth-factor consensus sequence, was found to be encoded as asparagine. Two sequence elements, tandemly located in the A-chain, are related to a sequence widespread among proteins which interact with C3b or C4b. Structural comparisons between different clones indicate that multiple polyadenylation sites are responsible for the length heterogeneity observed for C1r mRNA from liver and Hep G2 cells.

PMID:: 3030286; [PubMed - indexed for MEDLINE]
PMCID:: PMC1147487

Free PMC Article

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Secondary Source ID

GENBANK/X04701

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

P-TOLUENESULFONIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r. [Biochem J. 1987]
Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.
Arlaud GJ, Willis AC, Gagnon J. Biochem J. 1987 Feb 1; 241(3):711-20.
Nucleotide sequence of the cDNA coding for human complement C1r. [Biochemistry. 1986]
Nucleotide sequence of the cDNA coding for human complement C1r.
Leytus SP, Kurachi K, Sakariassen KS, Davie EW. Biochemistry. 1986 Aug 26; 25(17):4855-63.
Human genes for complement components C1r and C1s in a close tail-to-tail arrangement. [Proc Natl Acad Sci U S A. 1988]
Human genes for complement components C1r and C1s in a close tail-to-tail arrangement.
Kusumoto H, Hirosawa S, Salier JP, Hagen FS, Kurachi K. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7307-11.
Review [Cloning of cDNA for C3, the third component of complement (author's transl)]. [Ann Immunol (Paris). 1982]
Review [Cloning of cDNA for C3, the third component of complement (author's transl)].
Fey G, Domdey H, Wiebauer K, Odink K. Ann Immunol (Paris). 1982 Mar-Apr; 133C(2):189-97.
Review Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4. [Int Immunopharmacol. 2001]
Review Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.
Blanchong CA, Chung EK, Rupert KL, Yang Y, Yang Z, Zhou B, Moulds JM, Yu CY. Int Immunopharmacol. 2001 Mar; 1(3):365-92.

See reviews... See all...

Cited by 12 PubMed Central articles

Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement. [J Biol Chem. 2009]
Identification of the C1q-binding Sites of Human C1r and C1s: a refined three-dimensional model of the C1 complex of complement.
Bally I, Rossi V, Lunardi T, Thielens NM, Gaboriaud C, Arlaud GJ. J Biol Chem. 2009 Jul 17; 284(29):19340-8. Epub 2009 May 27.
A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s. [Biochem J. 2005]
A novel human complement-related protein, C1r-like protease (C1r-LP), specifically cleaves pro-C1s.
Ligoudistianou C, Xu Y, Garnier G, Circolo A, Volanakis JE. Biochem J. 2005 Apr 1; 387(Pt 1):165-73.
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. [EMBO J. 2002]
The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.
Budayova-Spano M, Lacroix M, Thielens NM, Arlaud GJ, Fontecilla-Camps JC, Gaboriaud C. EMBO J. 2002 Feb 1; 21(3):231-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (nucleotide/PMC)
Records in Gene identified from shared sequence and PMC links.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
MedGen (OMIM)
Related information in MedGen (OMIM)
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cloning and sequencing of full-length cDNA encoding the precursor of human compl...
Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.
Biochem J. 1986 Dec 15 ;240(3):783-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: