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Human gastrin-releasing peptide gene maps to chromosome band 18q21.
A complementary DNA clone encoding human pre-pro gastrin-releasing peptide, a 27-amino acid neuropeptide and putative growth factor, was used to determine the chromosomal location of this gene. Southern blot hybridization to genomic DNA isolated from a panel of human-rodent somatic cell hybrids unambiguously maps this gene to human chromosome 18. In situ chromosomal hybridization confirms the hybrid data and further localized the gene to chromosome band 18q21. Karyotypic abnormalities in tumors and inherited disease states which involve chromosome band 18q21 may now be studied for correlated changes in the structure and expression of the human GRP gene.
PMID: 3027901 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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ReviewMolecular analysis of the 18q- syndrome--and correlation with phenotype.
Kline AD, White ME, Wapner R, Rojas K, Biesecker LG, Kamholz J, Zackai EH, Muenke M, Scott CI Jr, Overhauser J.
Am J Hum Genet. 1993 May; 52(5):895-906.
[Am J Hum Genet. 1993]
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ReviewA controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system.
Comings DE.
Am J Hum Genet. 1987 Nov; 41(5):839-66.
[Am J Hum Genet. 1987]
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Use of yeast artificial chromosome clones for mapping and walking within human chromosome segment 18q21.3.
Silverman GA, Ye RD, Pollock KM, Sadler JE, Korsmeyer SJ.
Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7485-9.
[Proc Natl Acad Sci U S A. 1989]
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