Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome

Lucas Wauters; Tim Vanuytsel

doi:10.1016/j.coph.2018.09.005

Applications of peptide hormone ligands for the treatment of dumping and short bowel syndrome

Curr Opin Pharmacol. 2018 Dec:43:118-123. doi: 10.1016/j.coph.2018.09.005. Epub 2018 Sep 28.

Authors

Lucas Wauters¹, Tim Vanuytsel²

Affiliations

¹ Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, 3000 Leuven, Belgium; Leuven Intestinal Failure and Transplantation Center (LIFT), University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium.
² Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Herestraat 49, 3000 Leuven, Belgium; Leuven Intestinal Failure and Transplantation Center (LIFT), University Hospitals Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address: tim.vanuytsel@kuleuven.be.

PMID: 30273889
DOI: 10.1016/j.coph.2018.09.005

Abstract

Dumping syndrome is a common and debilitating complication of upper gastrointestinal surgery. Accelerated gastric emptying and dysregulated secretion of gastrointestinal (GI) hormones are involved in its pathophysiology. Pasireotide, a novel somatostatin analogue, improved dumping in a phase-2 study. Preliminary data suggest that the glucagon-like peptide-1 (GLP-1) analogue liraglutide can also improve dumping. Short bowel syndrome is the most common cause of intestinal failure and involves not only a loss of mucosal absorptive area but also hypersecretion and accelerated transit. GLP-2 is the best studied hormone involved in intestinal adaptation. An increasing body of evidence demonstrates that the GLP-2 analogue teduglutide reduces parenteral support needs. New GLP-2 analogues and analogues of other GI hormones such as liraglutide are being investigated as promising treatments in short bowel syndrome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dumping Syndrome / drug therapy*
Dumping Syndrome / metabolism
Dumping Syndrome / physiopathology
Gastrointestinal Agents / adverse effects
Gastrointestinal Agents / therapeutic use*
Gastrointestinal Motility / drug effects*
Gastrointestinal Tract / drug effects*
Gastrointestinal Tract / metabolism
Gastrointestinal Tract / physiopathology
Humans
Intestinal Absorption / drug effects*
Ligands
Liraglutide / therapeutic use
Peptides / therapeutic use
Receptors, Gastrointestinal Hormone / drug effects*
Receptors, Gastrointestinal Hormone / metabolism
Short Bowel Syndrome / drug therapy*
Short Bowel Syndrome / metabolism
Short Bowel Syndrome / physiopathology
Signal Transduction / drug effects
Somatostatin / analogs & derivatives
Somatostatin / therapeutic use
Treatment Outcome

Substances

Gastrointestinal Agents
Ligands
Peptides
Receptors, Gastrointestinal Hormone
Somatostatin
teduglutide
Liraglutide
pasireotide