Efficacy of vaccination with Skinner vaccine towards the prevention of herpes simplex virus induced cervical carcinoma in an experimental mouse model

M H Chen; Z Zhou; C E Hartley; M Cowan; G R Skinner

doi:10.1016/0264-410x(86)90139-8

Efficacy of vaccination with Skinner vaccine towards the prevention of herpes simplex virus induced cervical carcinoma in an experimental mouse model

Vaccine. 1986 Dec;4(4):249-52. doi: 10.1016/0264-410x(86)90139-8.

Authors

M H Chen, Z Zhou, C E Hartley, M Cowan, G R Skinner

PMID: 3026107
DOI: 10.1016/0264-410x(86)90139-8

Abstract

The incidence of cervical carcinoma, which had been induced by vaginal application of inactivated herpes simplex virus type 2 (HSV-2) with 20% croton oil, was significantly reduced in mice prevaccinated with the Skinner herpes vaccine. There was evidence of an immunological response in both vaccinated and unvaccinated mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antibodies, Viral / biosynthesis
Croton Oil / toxicity
Female
Herpes Genitalis / complications
Herpes Genitalis / prevention & control*
Mice
Simplexvirus / immunology*
Uterine Cervical Neoplasms / etiology
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / prevention & control*
Viral Vaccines / therapeutic use*

Substances

Antibodies, Viral
Viral Vaccines
Croton Oil