The intelligent devices in Internet of Things (IoT) not only provide services but also consider how to allocate heterogeneous resources and reduce resource consumption and service time as far as possible. This issue becomes crucial in the case of large-scale IoT environments. In order for the IoT service system to respond to multiple requests simultaneously and provide Pareto optimal decisions, we propose an immune-endocrine system inspired hierarchical coevolutionary multiobjective optimization algorithm (IE-HCMOA) in this paper. In IE-HCMOA, a multiobjective immune algorithm based on global ranking with vaccine is designed to choose superior antibodies. Meanwhile, we adopt clustering in top population to make the operations more directional and purposeful and realize self-adaptive searching. And we use the human forgetting memory mechanism to design two-level memory storage for the choice problem of solutions to achieve promising performance. In order to validate the practicability and effectiveness of IE-HCMOA, we apply it to the field of agricultural IoT service. The simulation results demonstrate that the proposed algorithm can obtain the best Pareto, the strongest exploration ability, and excellent performance than nondominated neighbor immune algorithms and NSGA-II.