The complex genetic and psychosocial influences on polysubstance misuse

Michael G Vaughn; Christopher P Salas-Wright; Dylan B Jackson

doi:10.1016/j.copsyc.2018.08.008

The complex genetic and psychosocial influences on polysubstance misuse

Curr Opin Psychol. 2019 Jun:27:62-66. doi: 10.1016/j.copsyc.2018.08.008. Epub 2018 Sep 5.

Authors

Michael G Vaughn¹, Christopher P Salas-Wright², Dylan B Jackson³

Affiliations

¹ School of Social Work, College for Public Health and Social Justice, Saint Louis University, Tegeler Hall, St. Louis, MO 63103, USA. Electronic address: michael.vaughn@slu.edu.
² School of Social Work, Boston University, USA.
³ Department of Criminal Justice, University of Texas at San Antonio, USA.

PMID: 30223196
DOI: 10.1016/j.copsyc.2018.08.008

Abstract

Polysubstance misuse is a costly and complex behavioral phenotype that is concurrent with internalizing and externalizing disorders. Research on genetic and psychosocial influences suggests that a life course framework composed of a transactional etiology sheds light on the complex nature of polysubstance misuse. Further, given the extensive comorbidity with mental illness and behavioral dysregulation, viewing polysubstance misuse as asymmetrical in the population is helpful for guiding broad decision-making around prevention and policy.

Publication types

Review

MeSH terms

Comorbidity*
Humans
Internal-External Control*
Stress, Psychological / psychology
Substance-Related Disorders / complications*
Substance-Related Disorders / physiopathology
Substance-Related Disorders / psychology*