Benzodiazepine receptor binding is not altered in human epileptogenic cortical foci

Neurology. 1986 Oct;36(10):1380-2. doi: 10.1212/wnl.36.10.1380.

Abstract

We measured benzodiazepine binding in cortical tissues from 13 patients with partial seizures. No differences in receptor density (Bmax) or affinity (Kd) were observed when epileptic foci were compared with nonspiking cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cerebral Cortex / metabolism*
  • Cerebral Cortex / pathology
  • Cerebral Cortex / physiopathology
  • Child
  • Electrophysiology
  • Epilepsy, Temporal Lobe / metabolism*
  • Epilepsy, Temporal Lobe / pathology
  • Epilepsy, Temporal Lobe / physiopathology
  • Female
  • Humans
  • Male
  • Receptors, GABA-A / metabolism*

Substances

  • Receptors, GABA-A