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Int J Rad Appl Instrum A. 1986;37(5):433-4.

An improved synthesis of (3-N-[11C]methyl)spiperone.

Abstract

An improved radiochemical synthesis of (3-N-[11C]methyl) spiperone is reported. The radiotracer was prepared by N-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (C-18 HPLC). The average radiochemical yield was approximately 21% end-of-synthesis (EOS) with an average specific activity of over 2750 mCi/mumol EOS. The total time for synthesis and specific activity determination was approximately 21 min.

PMID:
3019944
[PubMed - indexed for MEDLINE]
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