Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Kuddusi Teberik; Mehmet Tahir Eski; Ege Gulec Balbay; Murat Kaya

doi:10.12669/pjms.344.15018

Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome

Pak J Med Sci. 2018 Jul-Aug;34(4):817-822. doi: 10.12669/pjms.344.15018.

Authors

Kuddusi Teberik¹, Mehmet Tahir Eski², Ege Gulec Balbay³, Murat Kaya⁴

Affiliations

¹ Kuddusi Teberik, MD.Assistant Professor, Department of Ophthalmology, Duzce University Medical School, Duzce, Turkey.
² Mehmet Tahir Eski, MD.Ministry of Health Bingol State Hospital, Bingol, Turkey.
³ Ege Gulec Balbay, MD.Associate Professor, Department of Chest Diseases, Duzce University Medical School, Duzce, Turkey.
⁴ Murat Kaya, MD.Professor, Department of Ophthalmology, Duzce University Medical School, Duzce, Turkey.

Abstract

Objective: To evaluate the intraocular pressure (IOP), central corneal thickness (CCT), and peripapillary retinal nerve fiber layer (RNFL) thickness in Patients with Obstructive Sleep Apnea Syndrome.

Methods: In this prospective study, 103 patients with OSAS (study group) and 37 healthy subjects were enrolled. All participants underwent comprehensive ophthalmic examinations. Mean outcome measures were intraocular pressure by Goldmann applanation tonometry, CCT measurement using ultrasound pachymeter and peripapillary RNFL thickness measured by spectral-domain optical coherence tomography.

Results: The differences between the mean values of RNFL thickness in all quadrants were similar in both groups and were not statistically significant (p=0.274). The IOP and CCT measurement averages of all patients with OSAS were lower than the control group. However, this difference was not statistically significant. There was no correlation between the apnea-hypopnea index, lowest oxygen saturation (LAST) or Body Mass Index (BMI) and the peripapillary RNFL thickness, IOP or CCT when OSAS group was divided by severity.

Conclusions: The study results suggest that peripapillary RNFL thickness, IOP or CCT did not differ significantly between OSAS and control groups. We also found no correlation between apnea severity (AHI), lowest oxygen saturation (LAST) and BMI and RNFL, CCT and IOP.

Keywords: Central corneal thickness; Obstructive sleep apnea syndrome; Retinal nerve fiber layer thickness; Spectral-domain optical coherence tomography.