Early signals in the mitogenic response

Science. 1986 Oct 10;234(4773):161-6. doi: 10.1126/science.3018928.

Abstract

Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.

Publication types

  • Review

MeSH terms

  • Animals
  • Bombesin / pharmacology
  • Cell Line
  • Cell Membrane / metabolism
  • Cell Nucleus / metabolism
  • Cyclic AMP / metabolism
  • Cytosol / metabolism
  • DNA / biosynthesis
  • Enzyme Activation
  • ErbB Receptors
  • Growth Substances / pharmacology*
  • Interphase
  • Ions / metabolism
  • Mitogens / pharmacology*
  • Mitosis
  • Models, Biological
  • Oncogenes
  • Phosphorylation
  • Platelet-Derived Growth Factor / pharmacology*
  • Protein Kinase C / metabolism
  • Receptors, Cell Surface / metabolism

Substances

  • Growth Substances
  • Ions
  • Mitogens
  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • DNA
  • Cyclic AMP
  • ErbB Receptors
  • Protein Kinase C
  • Bombesin