The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials

K C Nune; I Montes; V S Y Injeti; M C Somani; R D K Misra

doi:10.1016/j.jmbbm.2018.08.033

The determining role of nanoscale mechanical twinning on cellular functions of nanostructured materials

J Mech Behav Biomed Mater. 2018 Dec:88:185-195. doi: 10.1016/j.jmbbm.2018.08.033. Epub 2018 Aug 24.

Authors

K C Nune¹, I Montes¹, V S Y Injeti¹, M C Somani², R D K Misra³

Affiliations

¹ Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX 79968, USA.
² Department of Mechanical Engineering, The University of Oulu, P.O. Box 4200, 90014 Oulu, Finland.
³ Department of Metallurgical, Materials and Biomedical Engineering, University of Texas at El Paso, 500 W. University Avenue, El Paso, TX 79968, USA. Electronic address: dmisra2@utep.edu.

PMID: 30173071
DOI: 10.1016/j.jmbbm.2018.08.033

Abstract

Considering that micromotions generated at the bone-implant interface under physiological loading introduce mechanical strain on the tissue and surface of the implant and that strain can be introduced during processing of the biomedical device, we elucidate here the interplay between mechanically-induced nanoscale twinning in austenitic stainless steel on osteoblast functions. Mechanically-induced nanoscale twinning significantly impacted cell attachment, cell-substrate interactions, proliferation, and subsequent synthesis of prominent proteins (fibronectin, actin, and vinculin). Twinning was beneficial in favorably modulating cellular activity and contributed to small differences in hydrophilicity and nanoscale roughness in relation to the untwinned surface.

Keywords: Austenitic nanograined stainless steel; Mechanically-induced twinning; Osteoblast functions; Plastic strain; Protein.

MeSH terms

3T3 Cells
Animals
Biocompatible Materials / chemistry*
Biocompatible Materials / pharmacology*
Cell Adhesion / drug effects
Cell Communication / drug effects
Cell Proliferation / drug effects
Mechanical Phenomena*
Mice
Nanostructures / chemistry*
Nanotechnology*
Tensile Strength
Wettability

Substances

Biocompatible Materials