Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration

Yang Xia; Jianfei Sun; Liang Zhao; Feimin Zhang; Xing-Jie Liang; Yu Guo; Michael D Weir; Mark A Reynolds; Ning Gu; Hockin H K Xu

doi:10.1016/j.biomaterials.2018.08.040

Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration

Biomaterials. 2018 Nov:183:151-170. doi: 10.1016/j.biomaterials.2018.08.040. Epub 2018 Aug 21.

Authors

Yang Xia¹, Jianfei Sun², Liang Zhao³, Feimin Zhang⁴, Xing-Jie Liang⁵, Yu Guo⁶, Michael D Weir⁷, Mark A Reynolds⁷, Ning Gu⁸, Hockin H K Xu⁹

Affiliations

¹ Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China; Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China; Department of Advanced Oral Sciences & Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
² Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China.
³ Department of Advanced Oral Sciences & Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
⁴ Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, Jiangsu 215123, China.
⁵ Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.
⁶ Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
⁷ Department of Advanced Oral Sciences & Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
⁸ Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu 210096, China; Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, Jiangsu 215123, China. Electronic address: guning@seu.edu.cn.
⁹ Department of Advanced Oral Sciences & Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology and Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: hxu@umaryland.edu.

PMID: 30170257
DOI: 10.1016/j.biomaterials.2018.08.040

Abstract

Novel strategies utilizing magnetic nanoparticles (MNPs) and magnetic fields are being developed to enhance bone tissue engineering efficacy. This article first reviewed cutting-edge research on the osteogenic enhancements via magnetic fields and MNPs. Then the current developments in magnetic strategies to improve the cells, scaffolds and growth factor deliveries were described. The magnetic-cell strategies included cell labeling, targeting, patterning, and gene modifications. MNPs were incorporated to fabricate magnetic composite scaffolds, as well as to construct delivery systems for growth factors, drugs and gene transfections. The novel methods using magnetic nanoparticles and scaffolds with magnetic fields and stem cells increased the osteogenic differentiation, angiogenesis and bone regeneration by 2-3 folds over those of the controls. The mechanisms of magnetic nanoparticles and scaffolds with magnetic fields and stem cells to enhance bone regeneration were identified as involving the activation of signaling pathways including MAPK, integrin, BMP and NF-κB. Potential clinical applications of magnetic nanoparticles and scaffolds with magnetic fields and stem cells include dental, craniofacial and orthopedic treatments with substantially increased bone repair and regeneration efficacy.

Keywords: Bone regeneration; Magnetic forces; Magnetic nanoparticles; Osteogenic differentiation; Scaffolds; Stem cells.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bone Regeneration*
Bone and Bones / cytology
Bone and Bones / metabolism
Cell Differentiation
Drug Delivery Systems
Gene Transfer Techniques
Humans
Intercellular Signaling Peptides and Proteins / administration & dosage
Magnetic Fields*
Magnetite Nanoparticles / chemistry*
Osteogenesis*
Signal Transduction
Stem Cells / cytology*
Stem Cells / metabolism
Tissue Engineering / methods
Tissue Scaffolds / chemistry*
Transfection

Substances

Intercellular Signaling Peptides and Proteins
Magnetite Nanoparticles