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Direct regional assignment of the gene for vitamin D binding protein (Gc-globulin) to human chromosome 4q11-q13 and identification of an associated DNA polymorphism.
Using a characterized human vitamin D binding protein (DBP) cDNA probe and a panel of rodent X human somatic cell hybrids, we established the chromosomal location of the structural gene for DBP on human chromosome 4. In situ hybridization of 3H-labeled DBP cDNA to human metaphase chromosomes confirmed this assignment and allowed regional localization to bands 4q11-4q13. A restriction fragment length polymorphism associated with the DBP gene that should prove useful in future linkage studies was identified with the enzyme BamHI.
PMID: 3015768 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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The human vitamin D-binding protein gene contains locus control determinants sufficient for autonomous activation in hepatic chromatin.
Hiroki T, Song YH, Liebhaber SA, Cooke NE.
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[Nucleic Acids Res. 2006]
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Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family.
Nishio H, Dugaiczyk A.
Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):7557-61.
[Proc Natl Acad Sci U S A. 1996]
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True hermaphroditism in a 46,XY individual, caused by a postzygotic somatic point mutation in the male gonadal sex-determining locus (SRY): molecular genetics and histological findings in a sporadic case.
Braun A, Kammerer S, Cleve H, Löhrs U, Schwarz HP, Kuhnle U.
Am J Hum Genet. 1993 Mar; 52(3):578-85.
[Am J Hum Genet. 1993]
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