There are two gene sequences for human apolipoprotein CI (apo CI) on chromosome 19, one of which is 4 kb from the gene for apo E

Biochem Biophys Res Commun. 1986 May 14;136(3):876-84. doi: 10.1016/0006-291x(86)90414-6.

Abstract

A cDNA probe corresponding to the mRNA sequence for apolipoprotein E (apo E) was used to screen two independently-constructed human genomic libraries. Two recombinants (lambda E-2, and lambda E2-1), isolated using the apo E cDNA probe, also contain part or all of the apo CI gene. Hybridisation studies using both apo E and apo CI cDNA probes show that these two genes are in the same orientation and separated by 4 kb.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein C-I
  • Apolipoproteins C / genetics*
  • Apolipoproteins E / genetics*
  • Base Sequence
  • Chromosomes, Human, 19-20*
  • DNA / analysis
  • DNA Restriction Enzymes / metabolism
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII
  • Deoxyribonucleases, Type II Site-Specific*
  • Humans
  • Nucleic Acid Hybridization
  • Polymorphism, Genetic

Substances

  • Apolipoprotein C-I
  • Apolipoproteins C
  • Apolipoproteins E
  • DNA
  • DNA Restriction Enzymes
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII
  • endodeoxyribonuclease SacI
  • CTGCAG-specific type II deoxyribonucleases
  • Deoxyribonucleases, Type II Site-Specific
  • TCGA-specific type II deoxyribonucleases