Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

Mai Phuong Thao; Pham Vo Anh Tuan; Le Gia Hoang Linh; Lam Van Hoang; Phan Huu Hen; Le Tuyet Hoa; Hoang Anh Vu; Do Duc Minh

doi:10.1155/2018/7965346

Association of HLA-B^∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

Int J Endocrinol. 2018 Jul 5:2018:7965346. doi: 10.1155/2018/7965346. eCollection 2018.

Authors

Mai Phuong Thao¹, Pham Vo Anh Tuan², Le Gia Hoang Linh³, Lam Van Hoang², Phan Huu Hen², Le Tuyet Hoa⁴, Hoang Anh Vu³, Do Duc Minh^{2

3}

Affiliations

¹ Department of Physiology, Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
² Department of Endocrinology, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
³ Center for Molecular Biomedicine, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
⁴ Department of Internal Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

Abstract

Background: HLA-B^∗38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients.

Methods: HLA-B^∗38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls.

Results: Frequency of HLA-B^∗38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8-120.2).

Conclusions: HLA-B^∗38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.