Abstract
Lymphoma presenting with ulceration is not typical. We report a case of relapsed DLBCL in a 73-year-old man presenting with a chronic non-healing leg ulcer. He has underlying varicose veins with recurrent venous ulcers. This patient was diagnosed to have DLBCL six years earlier when he presented with recurrent epistaxis originating from a left nasal cavity nodule. Complete resolution was achieved after eight cycles of R-CHOP and intrathecal methotrexate. For this current problem, this patient was treated with rituximab combined with chemotherapy which resulted in healing of the ulcer.
MeSH terms
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Aged
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Antibodies, Monoclonal, Murine-Derived / administration & dosage
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Antibodies, Monoclonal, Murine-Derived / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cyclophosphamide / administration & dosage
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Cyclophosphamide / therapeutic use
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Diagnosis, Differential
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Doxorubicin / administration & dosage
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Doxorubicin / therapeutic use
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Humans
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Leg Ulcer / diagnosis*
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Lymphoma, Large B-Cell, Diffuse / diagnosis*
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Lymphoma, Large B-Cell, Diffuse / drug therapy
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Male
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Methotrexate / administration & dosage
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Methotrexate / therapeutic use
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Prednisone / administration & dosage
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Prednisone / therapeutic use
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Recurrence
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Rituximab / administration & dosage
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Rituximab / therapeutic use
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Vincristine / administration & dosage
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Vincristine / therapeutic use
Substances
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Antibodies, Monoclonal, Murine-Derived
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R-CHOP protocol
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Rituximab
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Vincristine
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Doxorubicin
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Cyclophosphamide
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Prednisone
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Methotrexate