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    Hum Genet. 1986 May;73(1):77-80.

    The genes for human gastrin and cholecystokinin are located on different chromosomes.

    Lund T, Geurts van Kessel AH, Haun S, Dixon JE.

    The polypeptide hormones gastrin and cholecystokinin are structurally related, having the identical pentapeptide GWMDF located at their C-terminus. The precursors to these two hormones also show amino acid homology, suggesting that they may have a common ancestral origin. Recombinant DNA clones corresponding to gene fragments encoding human gastrin and cholecystokinin were used to determine their respective chromosomal localization by analyzing human-rodent cell lines. We have assigned the cholecystokinin gene to human chromosome 3q12-3pter and the gastrin gene to chromosome 17q.

    PMID: 3011648 [PubMed - indexed for MEDLINE]

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