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Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses.
The activities of the purine acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) against two human and five animal strains of cytomegalovirus were compared with those of acyclovir. DHPG was significantly more active than acyclovir against all but one (mouse cytomegalovirus) of the strains tested, with 50% effective doses ranging from 5 to 13 microM, as determined by plaque reduction assays in human embryonic lung (MRC-5) and human embryonic tonsil cells. Both DHPG and acyclovir inhibited virus replication at concentrations considerably lower than those necessary to inhibit cell proliferation. In mode-of-action studies, the triphosphates of DHPG and acyclovir inhibited human cytomegalovirus DNA polymerase. DHPG phosphorylation to the active triphosphate was enhanced in infected cells; however, this enzymatic activity was unrelated to thymidine kinase. In animal studies, DHPG was slightly more effective than acyclovir in reducing mouse cytomegalovirus-induced mortality.
PMID: 3010840 [PubMed - indexed for MEDLINE]
PMCID: PMC180226
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Cited by 16 PubMed Central articles
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Ganciclovir and cidofovir treatment of cytomegalovirus-induced myocarditis in mice.
Lenzo JC, Shellam GR, Lawson CM.
Antimicrob Agents Chemother. 2001 May; 45(5):1444-9.
[Antimicrob Agents Chemother. 2001]
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Antiviral guanosine analogs as substrates for deoxyguanosine kinase: implications for chemotherapy.
Herrström Sjöberg A, Wang L, Eriksson S.
Antimicrob Agents Chemother. 2001 Mar; 45(3):739-42.
[Antimicrob Agents Chemother. 2001]
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In vitro activities of methylenecyclopropane analogues of nucleosides and their phosphoralaninate prodrugs against cytomegalovirus and other herpesvirus infections.
Rybak RJ, Hartline CB, Qiu YL, Zemlicka J, Harden E, Marshall G, Sommadossi JP, Kern ER.
Antimicrob Agents Chemother. 2000 Jun; 44(6):1506-11.
[Antimicrob Agents Chemother. 2000]
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Patient Drug Information
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Acyclovir (Zovirax® )
Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and ...
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Ganciclovir (Cytovene® )
Ganciclovir capsules are used to treat cytomegalovirus (CMV) retinitis (eye infection that can cause blindness) in people whose immune system is not working normally. Ganciclovir capsules are used to treat CMV retinitis ...