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    Nature. 1986 Apr 17-23;320(6063):584-8.

    Cachectin and tumour necrosis factor as two sides of the same biological coin.

    Beutler B, Cerami A.

    Abstract

    In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

    PMID:
    3010124
    [PubMed - indexed for MEDLINE]

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