Hippocampal Mossy Cells Provide a Fate Switch for Adult Neural Stem Cells

Verónica C Piatti; Alejandro F Schinder

doi:10.1016/j.neuron.2018.07.044

Hippocampal Mossy Cells Provide a Fate Switch for Adult Neural Stem Cells

Neuron. 2018 Aug 8;99(3):425-427. doi: 10.1016/j.neuron.2018.07.044.

Authors

Verónica C Piatti¹, Alejandro F Schinder²

Affiliations

¹ Laboratorio de Plasticidad Neuronal, Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina.
² Laboratorio de Plasticidad Neuronal, Fundación Instituto Leloir-Instituto de Investigaciones Bioquímicas de Buenos Aires-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Patricias Argentinas 435, Buenos Aires C1405BWE, Argentina. Electronic address: aschinder@leloir.org.ar.

PMID: 30092210
DOI: 10.1016/j.neuron.2018.07.044

Abstract

The pathways that convert neural stem cells (NSCs) into functional neurons in the adult hippocampus are tightly regulated. In this issue of Neuron, Yeh et al. (2018) demonstrate that the activity of dentate mossy cells determines the balance between quiescence and activation of NSCs.

Keywords: c-Fos; dentate gyrus; inhibition; neurogenesis; neuronal differentiation; niche; proliferation; quiescence.

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MeSH terms

Adult
Adult Stem Cells*
Cell Differentiation
Hippocampus
Humans
Mossy Fibers, Hippocampal
Neural Stem Cells*
Neurogenesis