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Calcif Tissue Int. 1986 Feb;38(2):123-5.

Omeprazole, a specific inhibitor of H+-K+-ATPase, inhibits bone resorption in vitro.

Abstract

Omeprazole has been previously shown to block gastric acid secretion by specific inhibition of gastric parietal cell membrane H+-K+-ATPase. It is now demonstrated that similar concentrations of omeprazole will inhibit PGE2- and PTH-stimulated 45Ca++ release from prelabelled neonatal mouse calvariae without affecting the viability of cultured calvaria explants.

PMID:
3006888
[PubMed - indexed for MEDLINE]
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