Muscle, a conduit to brain for hormonal control of behavior

Barney A Schlinger; Ketema Paul; D Ashley Monks

doi:10.1016/j.yhbeh.2018.07.002

Muscle, a conduit to brain for hormonal control of behavior

Horm Behav. 2018 Sep:105:58-65. doi: 10.1016/j.yhbeh.2018.07.002. Epub 2018 Aug 1.

Authors

Barney A Schlinger¹, Ketema Paul², D Ashley Monks³

Affiliations

¹ Department of Integrative Biology and Physiology, University of California, Los Angeles, United States of America; Department of Ecology and Evolutionary Biology, University of California, Los Angeles, United States of America; Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, United States of America; Smithsonian Tropical Research Institute, Panama City, Panama. Electronic address: schlinge@lifesci.ucla.edu.
² Department of Integrative Biology and Physiology, University of California, Los Angeles, United States of America; Laboratory of Neuroendocrinology, Brain Research Institute, University of California, Los Angeles, United States of America.
³ Department of Psychology, University of Toronto Mississauga, Canada; Cell and Systems Biology, University of Toronto, Canada.

PMID: 30040953
DOI: 10.1016/j.yhbeh.2018.07.002

Abstract

SBN Elsevier Lecture Investigation into mechanisms whereby hormones control behavior often starts with actions on central nervous system (CNS) motivation and motor systems and is followed by assessment of CNS drive of coordinated striated muscle contractions. Here we turn this perspective on its head by discussing ways in which hormones might first act on muscle that then secondarily drive upstream the evolution and function of the CNS. While there is a lengthy history for consideration of this perspective, newly discovered properties of muscle signaling reveal novel mechanisms that may well be captured by endocrine systems and thus of interest to behavioral endocrinologists.

Keywords: Androgens; Bmal1; Bulbocavernosus; Circadian rhythms; Cross-talk; Manakins; SNB; Sleep.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Behavior, Animal / drug effects*
Behavior, Animal / physiology
Birds / physiology
Brain / drug effects
Brain / metabolism*
Courtship
Endocrine System / physiology
Feedback, Sensory / drug effects
Feedback, Sensory / physiology
Hormones / metabolism*
Hormones / pharmacology*
Muscles / physiology*
Nerve Net / drug effects
Nerve Net / physiology
Neurosecretory Systems / physiology
Posture / physiology

Substances

Hormones

Grants and funding

R01 NS078410/NS/NINDS NIH HHS/United States