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Identification of three new Ig lambda-like genes in man.
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
PMID: 3003227 [PubMed - indexed for MEDLINE]
PMCID: PMC2188038
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Cited by 16 PubMed Central articles
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In situ visualisation of immunoglobulin genes in normal and malignant lymphoid cells.
Carvalho C, Telhada M, do Carmo-Fonseca M, Parreira L.
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[Clin Mol Pathol. 1995]
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Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia.
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J Exp Med. 1998 Jan 5; 187(1):71-7.
[J Exp Med. 1998]
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J Exp Med. 1996 Feb 1; 183(2):421-9.
[J Exp Med. 1996]
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