Abstract
The epidemiology of Coxiella burnetii infection in the United States is not well characterized. We report a case-patient with C. burnetii endocarditis and meningitis. Infection was diagnosed by detecting high serologic titers for C. burnetii and confirmed by sequencing of C. burnetii 16S rRNA isolated from resected valvular tissue and PCR of cerebrospinal fluid.
Keywords:
California; Coxiella burnetii; Q fever; United States; bacteria; endocarditis; epidemiology; human infection; meningitis; meningitis/encephalitis.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Antibodies, Bacterial / blood
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California / epidemiology
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Coxiella burnetii / isolation & purification*
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Doxycycline / administration & dosage
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Doxycycline / therapeutic use
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Endocarditis, Bacterial / epidemiology
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Endocarditis, Bacterial / microbiology*
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Endocarditis, Bacterial / therapy
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Humans
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Hydroxychloroquine / administration & dosage
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Hydroxychloroquine / therapeutic use
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Male
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Meningitis, Bacterial / epidemiology
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Meningitis, Bacterial / microbiology*
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Q Fever / epidemiology*
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Q Fever / pathology*
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RNA, Bacterial / genetics
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RNA, Ribosomal, 16S / genetics
Substances
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Anti-Bacterial Agents
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Antibodies, Bacterial
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Immunoglobulin G
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Immunoglobulin M
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RNA, Bacterial
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RNA, Ribosomal, 16S
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Hydroxychloroquine
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Doxycycline