Diagnosis of Haemophilus influenzae Pneumonia by Nanopore 16S Amplicon Sequencing of Sputum

Emerg Infect Dis. 2018 Oct;24(10):1944-1946. doi: 10.3201/eid2410.180234. Epub 2018 Oct 17.

Abstract

We used deep sequencing of the 16S rRNA gene from sputum to identify Haemophilus influenza in a patient with community-acquired pneumonia. This method may be more effective than conventional diagnostic tests in pneumonia patients because of its speed and sensitivity.

Keywords: 16S amplicon sequencing; H. influenzae pneumonia; South Korea; bacteria; culture negative pneumonia; pneumonia.

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Biomarkers
  • Community-Acquired Infections / diagnosis
  • Community-Acquired Infections / microbiology
  • Haemophilus Infections / diagnosis*
  • Haemophilus Infections / drug therapy
  • Haemophilus Infections / microbiology*
  • Haemophilus influenzae / classification
  • Haemophilus influenzae / genetics*
  • Haemophilus influenzae / isolation & purification
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Kidney Failure, Chronic / complications
  • Male
  • Pneumonia, Bacterial / diagnosis*
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Bacterial / microbiology*
  • RNA, Ribosomal, 16S / genetics*
  • Sputum / microbiology*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Biomarkers
  • RNA, Ribosomal, 16S