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    Jpn Circ J. 1978 Apr;42(4):425-32.

    Cardiovascular effects of isoproterenol and possible antagonistic actions of propranolol and perhexiline.

    Matsukawa H, Okabe E, Sakamoto H, Cho YW, Ito H.

    Abstract

    A beta-adrenergic blocking activity of perhexiline was compared with that of propanolol. In the Langendorff's preparation of rabbits, canine heart-lung preparations, open-chest dog preparations and hind-limbs of dogs, perhexiline failed to block isoproterenol-induced changes in cardiovascular functions, which were effectively blocked by propranolol. These data suggest that perhexiline is not a beta-adrenergic receptor blocking agent.

    PMID:
    29976
    [PubMed - indexed for MEDLINE]

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