pH sensitive liposomes delivering tariquidar and doxorubicin to overcome multidrug resistance of resistant ovarian cancer cells

Colloids Surf B Biointerfaces. 2018 Oct 1:170:514-520. doi: 10.1016/j.colsurfb.2018.06.055. Epub 2018 Jun 27.

Abstract

Multidrug resistance of tumour cells is one of the most important hurdles in tumour chemotherapy. To overcome the multidrug resistance, we constructed a pH-sensitive liposome formulation (pHSL) by loading tariquidar (TQR) and DOX simultaneously in this work. The formulation showed high stability at pH 7.4 and excellent sensitivity at acidic pH, which facilitated the delivery of TQR and DOX into cells. Cellular experiments demonstrated that the pHSL/TQR/DOX 0.05 could almost restore the drug sensitivity of OVCAR8/ADR cells. Therefore, the pH sensitive liposome formulation pHSL/TQR/DOX 0.05 was very promising in treating resistant tumours.

Keywords: Combination therapy; Multidrug resistance; Tariquidar; pH sensitive liposome; tumour cells.

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Doxorubicin / administration & dosage*
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Drug Resistance, Multiple / drug effects*
  • Drug Resistance, Neoplasm / drug effects*
  • Drug Screening Assays, Antitumor
  • Flow Cytometry
  • Humans
  • Hydrogen-Ion Concentration
  • Liposomes / chemical synthesis
  • Liposomes / chemistry*
  • Particle Size
  • Quinolines / administration & dosage*
  • Quinolines / chemistry
  • Quinolines / pharmacology
  • Structure-Activity Relationship
  • Surface Properties
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Liposomes
  • Quinolines
  • Doxorubicin
  • tariquidar