J Biol Chem. 1985 Oct 5;260(22):12224-7.

Structure of the human prealbumin gene.

Tsuzuki T, Mita S, Maeda S, Araki S, Shimada K.

Abstract

Using cloned human prealbumin cDNA as a probe, Southern blot hybridization of human genomic DNA revealed that the prealbumin gene consists of an unique, single-copy DNA. The nucleotide sequences of the entire human prealbumin gene, including both 581 base pairs of the 5'- and 95 base pairs of the 3'-flanking sequences, were determined. The gene spans about 7.0 kilobase pairs and consists of four exons and three introns. As in most eukaryotic genes, the consensus TATA and CAAT sequences are found 30 and 101 nucleotides, respectively, upstream from the putative cap site, and a polyadenylation signal sequence AA-TAAA is found in the 3'-untranslated region. Unexpectedly, two independent open reading frames provided with respective regulatory sequences were found within the gene: one in the first intron and the other in the third intron.

PMID:: 2995367; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Secondary Source ID

GENBANK/M11844

LinkOut - more resources

Full Text Sources

HighWire Press - PDF

Medical

Genes and Gene Therapy - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Structure and expression of the mouse prealbumin gene. [J Biochem. 1986]
Structure and expression of the mouse prealbumin gene.
Wakasugi S, Maeda S, Shimada K. J Biochem. 1986 Jul; 100(1):49-58.
Isolation and complete nucleotide sequence of the gene for bovine parathyroid hormone. [Gene. 1984]
Isolation and complete nucleotide sequence of the gene for bovine parathyroid hormone.
Weaver CA, Gordon DF, Kissil MS, Mead DA, Kemper B. Gene. 1984 Jun; 28(3):319-29.
Structure and expression of the rat transthyretin (prealbumin) gene. [J Biol Chem. 1988]
Structure and expression of the rat transthyretin (prealbumin) gene.
Fung WP, Thomas T, Dickson PW, Aldred AR, Milland J, Dziadek M, Power B, Hudson P, Schreiber G. J Biol Chem. 1988 Jan 5; 263(1):480-8.
Complete nucleotide sequence of the gene for human interleukin 1 alpha. [Nucleic Acids Res. 1986]
Complete nucleotide sequence of the gene for human interleukin 1 alpha.
Furutani Y, Notake M, Fukui T, Ohue M, Nomura H, Yamada M, Nakamura S. Nucleic Acids Res. 1986 Apr 25; 14(8):3167-79.
Review [Analysis of genetic structure with radioisotopes]. [Radioisotopes. 1985]
Review [Analysis of genetic structure with radioisotopes].
Tsuchiya Y, Sakaki Y. Radioisotopes. 1985 Jul; 34(7):386-92.

See reviews... See all...

Cited by 15 PubMed Central articles

Review Transthyretin-related familial amyloidotic polyneuropathy-Progress in Kumamoto, Japan (1967-2010)-. [Proc Jpn Acad Ser B Phys Biol ...]
Review Transthyretin-related familial amyloidotic polyneuropathy-Progress in Kumamoto, Japan (1967-2010)-.
Araki S, Ando Y. Proc Jpn Acad Ser B Phys Biol Sci. 2010; 86(7):694-706.
Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met. [Am J Pathol. 2004]
Cysteine 10 is a key residue in amyloidogenesis of human transthyretin Val30Met.
Takaoka Y, Ohta M, Miyakawa K, Nakamura O, Suzuki M, Takahashi K, Yamamura K, Sakaki Y. Am J Pathol. 2004 Jan; 164(1):337-45.
A new isoleucine substitution of Val-20 in transthyretin tetramers selectively impairs dimer-dimer contacts and causes systemic amyloidosis. [Proc Natl Acad Sci U S A. 1996]
A new isoleucine substitution of Val-20 in transthyretin tetramers selectively impairs dimer-dimer contacts and causes systemic amyloidosis.
Jenne DE, Denzel K, Blätzinger P, Winter P, Obermaier B, Linke RP, Altland K. Proc Natl Acad Sci U S A. 1996 Jun 25; 93(13):6302-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structure of the human prealbumin gene.
Structure of the human prealbumin gene.
J Biol Chem. 1985 Oct 5 ;260(22):12224-7.

PubMed
Estriol and its conjugates in late pregnancy determined by extraction with Carbo...
Estriol and its conjugates in late pregnancy determined by extraction with Carbopack B and liquid chromatography with fluorometric detection.
Clin Chem. 1985 Oct ;31(10):1698-702.

PubMed
Nucleotide sequence of the gene for human factor IX (antihemophilic factor B).
Nucleotide sequence of the gene for human factor IX (antihemophilic factor B).
Biochemistry. 1985 Jul 2 ;24(14):3736-50.

PubMed
A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities i...
A paradoxical effect of hydralazine on prolyl and lysyl hydroxylase activities in cultured human skin fibroblasts.
Arch Biochem Biophys. 1985 Sep ;241(2):356-63.

PubMed
Transformation associated p53 protein is encoded by a gene on human chromosome 1...
Transformation associated p53 protein is encoded by a gene on human chromosome 17.
Somat Cell Mol Genet. 1985 Sep ;11(5):505-10.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: