Abstract
Serum glucose was elevated immediately after ip administration of a single large dose of fluoride (NaF 35 mg/kg) to rats. Moreover, elevation of serum glucose following ip administration of 35 mg/kg of fluoride to rats was suppressed by adrenalectomy, dibenamine, or propranolol, but not by thyroid-parathyroidectomy. The elevation of serum glucose was associated with enhancement of glucose-6-phosphatase activities in liver and kidney in fluoride-treated rats.
MeSH terms
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17-Hydroxycorticosteroids / blood
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17-Hydroxycorticosteroids / urine
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Adrenal Glands / drug effects*
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Animals
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Blood Glucose*
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Dibenzylchlorethamine / pharmacology
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Epinephrine / pharmacology
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Gluconeogenesis / drug effects
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Glucose-6-Phosphatase / metabolism
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Glycolysis / drug effects
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Injections, Intraperitoneal
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Kidney / drug effects
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Kidney / metabolism
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Liver / drug effects
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Liver / enzymology
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Male
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Parathyroid Glands / surgery
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Propranolol / pharmacology
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Rats
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Rats, Inbred Strains
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Sodium Fluoride / antagonists & inhibitors
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Sodium Fluoride / pharmacology*
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Thyroidectomy
Substances
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17-Hydroxycorticosteroids
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Blood Glucose
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Dibenzylchlorethamine
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Sodium Fluoride
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Propranolol
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Glucose-6-Phosphatase
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Epinephrine