Abstract
The coding sequences for the hepatitis B virus surface antigen, the herpes simplex virus glycoprotein D, and the influenza virus hemagglutinin were inserted into a single vaccinia virus genome. Rabbits inoculated intravenously or intradermally with this polyvalent vaccinia virus recombinant produced antibodies reactive to all three authentic foreign antigens. In addition, the feasibility of multiple rounds of vaccination with recombinant vaccinia virus was demonstrated.
MeSH terms
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Animals
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Antigens, Viral / genetics*
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DNA, Recombinant
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Glycoproteins / genetics
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Glycoproteins / immunology
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Hemagglutinins, Viral / genetics
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Hemagglutinins, Viral / immunology
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Hepatitis B Surface Antigens / genetics
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Hepatitis B Surface Antigens / immunology
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Influenza A virus / genetics
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Influenza A virus / immunology
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Rabbits
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Simplexvirus / genetics
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Simplexvirus / immunology
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Vaccination
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Vaccinia virus / genetics*
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Vaccinia virus / immunology
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Viral Proteins / genetics*
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Viral Proteins / immunology
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Viral Vaccines / genetics*
Substances
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Antigens, Viral
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DNA, Recombinant
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Glycoproteins
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Hemagglutinins, Viral
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Hepatitis B Surface Antigens
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Viral Proteins
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Viral Vaccines