A Microbial Drugstore for Motility

John F Cryan; Gerard Clarke; Timothy G Dinan; Harriet Schellekens

doi:10.1016/j.chom.2018.05.020

A Microbial Drugstore for Motility

Cell Host Microbe. 2018 Jun 13;23(6):691-692. doi: 10.1016/j.chom.2018.05.020.

Authors

John F Cryan¹, Gerard Clarke², Timothy G Dinan², Harriet Schellekens³

Affiliations

¹ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
² Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
³ APC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.

PMID: 29902430
DOI: 10.1016/j.chom.2018.05.020

Abstract

While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a regulator of gastrointestinal motility.

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MeSH terms

Bacteria*
Cell Movement
Digestive System
Microbiota*
Signal Transduction