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Nature. 1985 Jun 20-26;315(6021):641-7.

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs.


Two distinct but distantly related complementary DNAs encoding proteins sharing human interleukin-1 (IL-1) activity (termed IL-1 alpha and IL-1 beta), were isolated from a macrophage cDNA library. The primary translation products of the genes are 271 and 269 amino acids long, although expression in Escherichia coli of the carboxy-terminal 159 and 153 amino acids produces IL-1 biological activity.

[PubMed - indexed for MEDLINE]
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