Studies on the Biocompatibility of Poly(diethyl vinyl-phosphonate) with a New Fluorescent Marker

Macromol Rapid Commun. 2018 Aug;39(15):e1800259. doi: 10.1002/marc.201800259. Epub 2018 Jun 11.

Abstract

Utilization of group transfer polymerization for the synthesis of poly(diethyl vinylphosphonate) (PDEVP) allows its controlled end-group functionalization. Thus, a new fluorescent chromophore/PDEVP conjugate is prepared and subjected to biocompatibility tests on two different human cell lines. In contrast to the previous studies, the tagged polymer is not absorbed by cells from the solution and has nearly no impact on cell mortality rate.

Keywords: biocompatibility; fluorescence; polyvinylphosphonates; thermoresponsive polymers; water-soluble polymers.

MeSH terms

  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Cell Line
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / pharmacology
  • HEK293 Cells
  • Humans
  • Molecular Structure
  • Organophosphonates / chemical synthesis*
  • Organophosphonates / chemistry
  • Organophosphonates / pharmacology
  • Polymers / chemical synthesis*
  • Polymers / chemistry
  • Polymers / pharmacology
  • Structure-Activity Relationship
  • Vinyl Compounds / chemical synthesis*
  • Vinyl Compounds / chemistry
  • Vinyl Compounds / pharmacology

Substances

  • Biocompatible Materials
  • Fluorescent Dyes
  • Organophosphonates
  • Polymers
  • Vinyl Compounds
  • poly(diethyl vinylphosphonate)