Serum α1-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease

R M Heilmann; N Grützner; J A Hokamp; J A Lidbury; P G Xenoulis; J S Suchodolski; M B Nabity; R Cianciolo; J M Steiner

doi:10.1016/j.tvjl.2018.04.017

Serum α₁-proteinase inhibitor concentrations in dogs with exocrine pancreatic disease, chronic hepatitis or proteinuric chronic kidney disease

Vet J. 2018 Jun:236:68-71. doi: 10.1016/j.tvjl.2018.04.017. Epub 2018 Apr 30.

Authors

R M Heilmann¹, N Grützner², J A Hokamp³, J A Lidbury⁴, P G Xenoulis⁵, J S Suchodolski⁴, M B Nabity⁶, R Cianciolo⁷, J M Steiner⁴

Affiliations

¹ Department for Small Animals, Veterinary Teaching Hospital, College of Veterinary Medicine, University of Leipzig, An den Tierkliniken 23, DE-04103 Leipzig, Germany; Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas Agricultural and Machinery (Texas A&M) University, College Station, TX 77843-4474, USA. Electronic address: romy.heilmann@kleintierklinik.uni-leipzig.de.
² Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas Agricultural and Machinery (Texas A&M) University, College Station, TX 77843-4474, USA; Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle-Wittenberg, DE-06120 Halle (Saale), Germany.
³ Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4474, USA; International Veterinary Renal Pathology Service, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA.
⁴ Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas Agricultural and Machinery (Texas A&M) University, College Station, TX 77843-4474, USA.
⁵ Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas Agricultural and Machinery (Texas A&M) University, College Station, TX 77843-4474, USA; Small Animal Clinic, Faculty of Veterinary Science, University of Thessaly, Karditsa 43100, Greece.
⁶ Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4474, USA.
⁷ International Veterinary Renal Pathology Service, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, USA.

PMID: 29871753
DOI: 10.1016/j.tvjl.2018.04.017

Abstract

Serum canine α₁-proteinase inhibitor (cα₁-PI) concentrations were evaluated in dogs with pancreatitis (n=24), exocrine pancreatic insufficiency (EPI; n=29), chronic hepatitis (CH; n=11) or proteinuric chronic kidney disease (CKD-P; n=61) to determine whether systemic proteinase/proteinase-inhibitor balance is altered in these conditions. Dogs with CKD-P had significantly lower cα₁-PI concentrations than dogs with pancreatitis, EPI or CH; 16% of dogs with CKD-P had serum cα₁-PI concentrations below the reference interval. Serum and urine cα₁-PI concentrations were inversely correlated in dogs with CKD-P, but not in dogs with CH. This suggests that renal loss of cα₁-PI contributes to decreased serum concentrations in dogs with CKD-P, while hepatic cα₁-PI synthesis with CH either is not compromised or is counterbalanced by extrahepatic production.

Keywords: Acute phase protein; Canine; Exocrine pancreatic insufficiency; Pancreatitis; α(1)-Antitrypsin.

MeSH terms

Animals
Dog Diseases / blood*
Dogs
Female
Hepatitis, Chronic / blood
Hepatitis, Chronic / veterinary*
Male
Pancreatic Diseases / blood
Pancreatic Diseases / veterinary*
Peptide Hydrolases
Protease Inhibitors / blood*
Renal Insufficiency, Chronic / blood
Renal Insufficiency, Chronic / veterinary*

Substances

Protease Inhibitors
Peptide Hydrolases